Continuous cell flocculation for recombinant antibody harvesting

What can cell culture flocculation offer for antibody purification processes

Study on Flocculation Efficiency for Harvesting Nannochloropsis oculata for Biodiesel Production

Flocculation is one of the principal steps in biodiesel production from microalgae. Eight different flocculants were analysed for their efficiency of flocculation of marine microalga, Nannochloropsis oculata. Maximum flocculation was observed as 93.80 and 87.33% with FeCl3 and Fe2(SO4)3 at a concentration of 0.4 and 0.6g/L respectively at 180min. Zinc salts achieved second maximum efficient flo...

Facile sand enhanced electro-flocculation for cost-efficient harvesting of Dunaliella salina.

Energy consumption and water resource in the cultivation and harvesting steps still need to be minimized for the popularization of the microalgae-based products. An efficient electro-flocculation method for harvesting Dunaliella Salina integrated with local sand has been successfully applied. Sand was effective for speeding up the processes of flocculation and sedimentation of algal flocs and t...

Optimization of Alkaline Flocculation for Harvesting of Scenedesmus quadricauda #507 and Chaetoceros muelleri #862

A response surface methodology (RSM) was used to evaluate the effects of pH and microalgal biomass concentration (BC) on alkaline flocculating activity for harvesting one freshwater green algae Scenedesmus quadricauda #507 and one marine diatom Chaetoceros muelleri #862. The pH value and BC were in range of 9.0–12.0 and 0.20–2.30 g/L, respectively. Very high regression coefficient between the v...

Industrial application of impurity flocculation to streamline antibody purification processes

2015 Flocculation technologies offer significant benefits to industrial mammalian cell culture processes, including increased clarification efficiency, impurity removal and process simplification. In this paper, the application and performance of flocculation technologies employed in the harvest process of monoclonal antibody Chinese hamster ovary cell culture are reviewed. Attention has been p...